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Micro-FTIR identifies osteodifferentiation markers in heterogeneous mesenchymal stem cell populations

delete2026-07-09
delete0
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OA
AI
J
João T.S. Martins
C
Clara B. Martins
J
João A. Rodrigues
I
Inês Graça
D
Daniela S. Bispo
A
Ana L. M. Batista de Carvalho
B
Brian J. Goodfellow
J
João F. Mano
M
Mariana B. Oliveira
M
Mariela M. Nolasco *
M
M. Paula M. Marques
P
Paulo J.A. Ribeiro-Claro
D
D.N. Rutledge
A
Ana M. Gil *
DOI：10.1016/j.aca.2026.345951delete
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Abstract

Abstract

En 中文
• Micro-FTIR tracks AMSC dynamic osteodifferentiation despite high variability. • A protein/lipid spectral signature describes high proliferation conditions. • Inter- and intra-sample heterogeneity describes osteodifferentiating cells. • An osteo-specific spectral signature is marker of osteodifferentiation extension. • Differentiation increases helical proteins, lipids & 1030 cm−1 phosphate band.
Keywords:
Mesenchymal stem cells
Osteogenic differentiation
Micro-FTIR
Vibrational spectroscopy
Microscopy
Chemometrics
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Journal

Analytica Chimica Acta cover
Analytica Chimica Acta
IF:
6
Papers:
3.3W
Citations:
6.1W

Organization

F
faculté de pharmacie
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48
Papers: 22
Citations: 1
U
university of coimbra
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939
Papers: 379
Citations: 1
U
University of Aveiro
Scholars:
1.8K
Papers: 690
Citations: 1.7W
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