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Microbiome remodeling during aging: Integrative multi-omics and spatiotemporal perspectives on immune and metabolic regulation
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DOI：10.1016/j.arr.2026.103269.png)
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Abstract
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• Aging reshapes the gut microbiome toward a less resilient and more heterogeneous ecosystem. • Microbiota–host crosstalk is a central driver of immunosenescence and metabolic dysfunction. • Microbial metabolites function as critical signaling hubs in aging-related pathophysiology. • Targeting the microbiome offers promising strategies for preventing and managing age-related diseases. • Spatial and spatiotemporal multi-omics provide a next-generation framework to decode microbiome–aging interactions.
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