.png){kind=icon}
Return
Microchip separations in reduced-gravity and hypergravity environments
.png){kind=icon}
PRE
AI
DOI：10.1021/ac051198e.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Microfabricated fluidics technology, e.g., lab-on-a-chip devices, offers many attractive features for performing chemistry and biochemistry on space-based platforms. We have constructed a portable, battery-operated microfluidic platform that was tested under reduced gravity and hypergravity conditions that would be experienced in space flight and launch. This device consisted of a microchip, microchip holder, two 0-8-kV high-voltage power supplies, a high-voltage switch, a solid-state diode-pumped green laser, an optical train, a channel photo-multiplier, and an inertial mass measurement unit all under the control of a laptop computer and powered by 10 D-cell alkaline batteries. The unit was tested on NASA's reduced gravity research aircraft at gravity levels that are relevant to NASA's intended use of bioreporter-based microchips for environmental monitoring of space and planetary environments on manned and unmanned spacecraft. Over the course of two flights, 834 fast electrophoretic separations of four amino acids were performed under a variety of gravitational environments including zero-g, Martian-g, lunar-g, and similar to 1.8-g. All separations were performed in less than 12 s and automatically analyzed. After correction with an internal migration standard, the migration time reproducibilities were all < 1 % relative standard deviation.
Keywords:
TOTAL ANALYSIS SYSTEMS
ELECTROCHEMICAL DETECTION
SURFACE MODIFICATION
POLY(DIMETHYLSILOXANE)
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
6.7
Papers:
4.7W
Citations:
15.9W
Organization
No organization information available
Cited Papers
A miniaturized high-voltage integrated power supply for portable microfluidic applications.png)
LAB ON A CHIP
LAB ON A CHIPIF5.4
PREAI
ShareSaveShareSaveShareSaveHand-held microanalytical instrument for chip-based electrophoretic separations of proteinsANALYTICAL CHEMISTRY
ANALYTICAL CHEMISTRYIF6.7
PREAI
ShareSaveShareSaveAn integrated fluorescence detection system in poly(dimethylsiloxane) for microfluidic applicationsANALYTICAL CHEMISTRY
ANALYTICAL CHEMISTRYIF6.7
PREAI
ShareSaveShareSaveDevelopment and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars
OAAI
OAAIShareSaveShareSave
View more