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Microcystin-LR hijacks mitochondrial bioenergetics and Wnt crosstalk: Unveiling a novel dual-pathway mechanism for adipogenesis dysregulation in environmental toxicology
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DOI：10.1016/j.cbpc.2025.110329.png)
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Abstract
En 中文
• Microcystin-LR (MC-LR) inhibits SVF cell viability, exerting toxic effects. • MC-LR damages mitochondrial function and promotes mitophagy in SVF cells. • MC-LR activates the Wnt/β-Catenin signaling pathway abnormally in the early stage of adipogenesis. • MC-LR significantly impairs adipogenesis in SVF cells.
Keywords:
Microcystin-LR
SVF cells
mitochondrial function
mitophagy
Wnt/β-Catenin signaling pathway
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