.png){kind=icon}
.png){kind=icon}
Return
Microhaplotypes in forensic genetics
.png){kind=icon}
PRE
AI
DOI：10.1016/j.fsigen.2018.09.009.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Microhaplotype loci (microhaps, MHs) are a novel type of molecular marker of less than 300 nucleotides, defined by two or more closely linked SNPs associated in multiple allelic combinations. The value of these markers is enhanced by massively parallel sequencing (MPS), which allows the sequencing of both parental haplotypes at each of the many multiplexed loci. This review describes the features of these multi-SNP markers and documents their value in forensic genetics, focusing on individualization, biogeographic ancestry inference, and mixture deconvolution. Foreseeable applications also include missing person identification, relationship testing, and medical diagnostic applications. The technique is not restricted to humans.
Keywords:
Microhaplotypes
Single nucleotide polymorphisms
Massively parallel sequencing
Biogeographic ancestry inference
Mixture deconvolution
Human identification
Missing person and relationship identification
Probabilistic genotyping
Clinical application
Non-human DNA
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.1
Papers:
2.7K
Citations:
5.8K