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Micrometer-Scale Biomechanical Characterization of Oral Mucosa Using Spatial Phase-Gradient Tracking Optical Coherence Elastography
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DOI：10.1002/jbio.70255.png)
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Abstract
En 中文
We present a custom-built, high-speed optical coherence elastography (OCE) system for non-invasive, quantitative assessment of oral tissue biomechanics. The system integrates low-frequency (10 Hz) air-driven elastic wave excitation with phase-resolved optical coherence tomography (OCT) for micrometer-scale elasticity mapping. A pilot study on human buccal mucosa (four healthy, four cancerous, one leukoplakia) revealed distinct biomechanical contrasts. Healthy tissues exhibited regular elastic wave propagation (approximate to 2.5 mu m displacement; 2.72 +/- 0.27 Pa modulus), while cancerous samples showed restricted displacement (approximate to 1 mu m; 9.51 +/- 0.95 Pa), indicating increased stiffness. The elastograms also visualized keratin layer thickening, rete peg elongation, and mild inflammatory infiltration. The leukoplakia specimen demonstrated intermediate stiffness (5.47 +/- 0.55 Pa), suggestive of early biomechanical alteration. The integration of air-pressure excitation with phase-resolved OCT enables a non-contact, repeatable, and sensitive elastographic method capable of detecting subtle mechanical changes, highlighting the system's potential for early oral cancer diagnosis and soft tissue biomechanical characterization.
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