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Microphysiological (“organ-on-a-chip”) models of pulmonary infections for developing novel anti-infectives
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DOI：10.1016/j.addr.2026.115917.png)
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Abstract
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• High complexity due to multiple cell types from different domains (mammals, bacteria). • Disease models address pathophysiological changes beyond the healthy state. • Mechanistic insights to lung infections enable rational drug development. • Examples of successful application for viral infections and antiviral drug testing. • Modelling chronic bacterial infections remains a major challenge.
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