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Microscale matrix defects suppress tension-dependent protrusions and stall collective cell migration
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DOI：10.1016/j.celrep.2026.117754.png)
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Abstract
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• Microscale defects on collagen-IV surfaces stall epithelial migration • Leader filopodia sense defects; cytoskeletal disruption propagates to followers • Collagen-I or stiffer substrates boost protrusions and prevent migratory stalling • Hypotonic media enhances membrane tension, softens cells, and reduces stalling
Keywords:
collective cell migration
collagen
mechanobiology
extracellular matrix
basement membrane
membrane tension
cell stiffness
CP: Cell biology
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