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Microscale strategies in engineering the pancreas: Toward clinical translation
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DOI：10.1016/j.addr.2026.115919.png)
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Abstract
En 中文
• Microscale OoC platforms improve scalable manufacturing of stem cell derived islets. • Engineering microenvironments control oxygen, shear and transport from manufacture to implant. • Microscale encapsulation balance immune protection with mass transport. • Integrated sensing enables functional monitoring of islets grafts pre- and post- implant.
Keywords:
Pancreas
Organ-on-a-Chip
Microenvironment
Biomanufacturing
Scale-up
Cell therapy encapsulation
Monitoring
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