logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
delete
arrow
Return

Microstructured liposome array

delete2005-12-27
delete42
PRE
AI
B
Barnabé Chaize
M
Michel Nguyen
T
Tristan Ruysschaert
L
le Berre, V
E
Emmanuelle Trévisiol
A
Anne‐Marie Caminade
J
Jean‐Pierre Majoral
G
Geneviève Pratviel
B
Bernard Meunier
M
Mathias Winterhalter
D
Didier Fournier *
DOI：10.1021/bc050273pdelete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Conversion of a DNA chip to a nanocapsule array was performed by grafting on a liposome an oligonucleotide complementary to an oligonucleotide bound to the array. Each liposome may be loaded by a soluble molecule or may present a hydrophobic or amphiphilic molecule inserted in its wall. To detect liposomes on the chip, we used fluorescent dyes encapsulated in the liposome internal volume or fluorescent lipids. We observed that an oligonucleotide-grafted liposome containing a defined dye specifically accumulated on the area where its complementary oligonucleotide had been spotted on the array. The virtually unlimited amount of addresses allows the specific binding of large amounts of liposomes in one single batch.
Keywords:
PROTEIN MICROARRAYS
DNA MICROARRAYS
GLASS SLIDES
ACETYLCHOLINESTERASE
ENCAPSULATION
BILAYERS

Journal

Bioconjugate Chemistry cover
Bioconjugate Chemistry
IF:
3.9
Papers:
7.2K
Citations:
1.6W

Organization

No organization information available