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Microwave-Assisted Cobinamide Synthesis
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DOI：10.1021/jo501364b.png)
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Abstract
En 中文
We present a new method for the preparation of cobinamide (CN)(2)Cbi, a vitamin B-12 precursor, that should allow its broader utility. Treatment of vitamin B-12 with only NaCN and heating in a microwave reactor affords (CN)(2)Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)(2)Cbi(c-lactone) synthesis. Treatment of (CN)(2)Cbi with triethanolamine led to (CN)(2)Cbi(c-lactam).
Keywords:
VITAMIN-B12
CYANIDE
DERIVATIVES
COBALAMIN
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