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Mimicking Tumor Hypoxia in a Glioblastoma-on-a-Chip
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DOI：10.1016/j.mtbio.2026.103548.png)
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Abstract
En 中文
• Biomimetic GBM-on-Chip recreates hypoxic tumor microenvironments. • GelMA and chitosan hydrogels support viable GBM and astrocyte co-cultures. • Chitosan hydrogel drives spontaneous cell autoaggregation into spheroids. • In silico modeling predicts oxygen gradients and hypoxic core formation. • Quantitative oxygen mapping validates chip-induced hypoxia predicted by simulations. • HIF1α staining confirmed cellular hypoxia.
Keywords:
Hydrogel
Organ-on-a-Chip
In silico modeling
3D tumor microenvironment
Glioblastoma
Hypoxia
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