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miRNA modules for precise, tunable control of gene expression

delete2025-12-19
delete0
PRE
AI
R
Rongrong Du
M
Michael Flynn
K
Karan Mahe
M
Monique Honsa
B
Bo Gu
D
Dongyang Li
S
Sean E. McGeary
V
Viviana Gradinaru
R
Ralf Jungmann
M
Michael B. Elowitz *
DOI：10.1016/j.molcel.2025.11.028delete
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Abstract

Abstract

En 中文
• Rationally designed synthetic miRNA circuits allow transgene dosage compensation • Multimerized weak miRNA-target sites exploit multivalent TNRC6-mediated regulation • Circuits are tunable, orthogonal, and portable across cell types • They reduce background in imaging and base-editing applications and function in vivo

Journal

Molecular Cell cover
Molecular Cell
IF:
16.6
Papers:
1.0W
Citations:
8.5W

Organization

C
California Institute of Technology
Scholars:
2.9W
Papers: 2.5W
Citations: 4.9W
L
Ludwig Maximilian University
Scholars:
43
Papers: 21
Citations: 0
H
Harvard Medical School
Scholars:
6.5W
Papers: 4.8W
Citations: 91
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