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Mitochondria-lysosome contacts in aging: a mechanistic interface linking organelle homeostasis and cellular decline
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DOI：10.1016/j.mad.2026.112191.png)
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Abstract
En 中文
MLCs form a dynamic interface between mitochondria and lysosomes. Rab7 cycling, Ca2+ flux, lipids, and pH tune MLCs structure and output. MLCs coordinate mitochondrial quality control and metabolic homeostasis. Aging remodels MLCs coupling and amplifies organelle decline and stress. MLCs provide mechanistic and therapeutic entry points in age-related disease.
Keywords:
Mitochondria-lysosome contacts
Rab7 cycling
Ca2+ flux
mitochondrial quality control
aging
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