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Mitochondria-targeted nanosystem-mediated delivery of cryptotanshinone for enhanced suppression of non-small cell lung cancer
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DOI：10.1016/j.biopha.2025.118927.png)
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Abstract
En 中文
• The potent anti-tumor effects of cryptotanshinone-polydopamine small molecular drug nanoparticles (PPRC). • PPRC induced a dose-dependent reduction in mitochondrial membrane potential in A549 cells, with concurrent disruption of mitochondrial function. • PPRC enhanced cryptotanshinone's ability to affect mitochondrial apoptosis and metabolism-related lipid levels. • A polydopamine-based nanomaterial targeting mitochondria and encapsulated cryptotanshinone to enhance cGAS/STING pathway.
Keywords:
Cryptotanshinone
Non-small cell lung cancer
Lipid metabolism
Mitochondrial apoptosis
CGAS/STING pathway
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