Mitochondrial complexome and import network

doi:10.1016/j.tcb.2023.10.004

Mitochondrial complexome and import network

2024-07-01

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DOI：10.1016/j.tcb.2023.10.004

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Abstract

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Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis, quality control, and signaling. The systematic analysis of protein complexes and interaction networks provided exciting insights into the structural and functional organization of mitochondria. Most mitochondrial proteins do not act as independent units, but are interconnected by stable or dynamic protein-protein interactions. Protein translocases are responsible for importing precursor proteins into mitochondria and form central elements of several protein interaction networks. These networks include molecular chaperones and quality control factors, metabolite channels and respiratory chain complexes, and membrane and organellar contact sites. Protein translocases link the distinct networks into an overarching network, the mitochondrial import network (MitimNet), to coordinate biogenesis, membrane organization and function of mitochondria.

Keywords:

TRANSLOCATION CONTACT SITES

TIM22 PROTEIN TRANSLOCASE

INNER-MEMBRANE

ER-MITOCHONDRIA

OUTER-MEMBRANE

PRESEQUENCE TRANSLOCASE

ACYLGLYCEROL KINASE

ORGANIZING SYSTEM

RESPIRATORY-CHAIN

SENGERS SYNDROME

Mitochondrial complexome and import network

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