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Mitochondrial-targeted cerium dioxide nanozymes enable the efficient regulation of oxidative stress and inflammation in acute lung injury
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DOI：10.1016/j.bioadv.2026.214937.png)
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Abstract
En 中文
• The authors designed a mitochondrial-targeted cerium dioxide nanozyme (named TC), which can deliver the cerium dioxide nanozymes to the mitochondria of macrophages at inflamed sites, thereby enhancing mitochondrial drug delivery efficiency. • The TC exhibited potent antioxidant and anti-inflammatory properties, significantly reducing the expression levels of reactive oxygen species (ROS) and pro-inflammatory cytokines. • The TC ameliorated pulmonary oxidative stress, attenuate inflammatory responses, and mitigate lung tissue damage in acute lung injury.
Keywords:
mitochondrial-targeted nanozymes
cerium dioxide
oxidative stress
inflammation
acute lung injury
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