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Mitotic memories of gene activity
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DOI：10.1016/j.ceb.2020.12.009.png)
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Abstract
En 中文
When cells enter mitosis, they undergo series of dramatic changes in their structure and function that severely hamper gene regulatory processes and gene transcription. This raises the question of how daughter cells efficiently recapitulate the gene expression profile of their mother such that cell identity can be preserved. Here, we review recent evidence supporting the view that distinct chromatin-associated mechanisms of gene-regulatory inheritance assist daughter cells in the post-mitotic reestablishment of gene activity with increased fidelity.
Keywords:
Mitotic bookmarking
Epigenetic mark
Mitosis
Transcription factor
Gene reactivation
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