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Mn(II) MRI contrast agents supported by unsymmetric pyridinophane-picolinate ligands
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DOI：10.1016/j.jinorgbio.2026.113377.png)
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Abstract
En 中文
• Unsymmetrical pyridinophane–picolinate ligands and their Mn(II) complexes are reported. • Methylation of secondary amine enhances chelator kinetic inertness. • Additional chelating arms improve stability but reduce kinetic inertness. • Relaxivity differences are not solely due to molecular weight. • One Mn(II) contrast agent shows optimal renal excretion in vivo.
Keywords:
Macrocyclic chelators
MRI contrast agents
9.4 T MRI studies
Relaxivity measurements
Thermodynamic stability
Kinetic inertness
BSA
Bovine Serum Albumin
CV
Cyclic Voltammetry
DCM
Dichloromethane
DPV
Differential Pulse Voltammetry
ESI
Electrospray Ionization
HEPES
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
HPLC
High Performance Liquid Chromatography
HR
High Resolution
Hz
Hertz
MeCN
Acetonitrile
MeOH
Methanol
MRI
Magnetic Resonance Imaging
MS
Mass Spectrometry
NMR
Nuclear Magnetic Resonance
SC-XRD
Single Crystal X-Ray Diffraction
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