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Mobilising Computational Strategies in Enzyme Inhibition: Reconciling Therapeutic Innovation and Environmental Integrity from Molecular Targets to Ecosystem Disruptors
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DOI：10.2174/0113892002420090251206171649.png)
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Abstract
En 中文
Enzyme inhibition has become a cornerstone of modern therapeutics, targeting key molecular pathways implicated in cancer, metabolic disorders, and infectious diseases. This review explores diverse strategies of enzyme inhibition from classical active site-directed inhibitors to innovative biofilm-targeting enzymatic cocktails, emphasising their clinical utility. Beyond medicine, enzyme inhibitors are routinely employed to modulate nitrogen fixation, methanogenesis, and microbial dynamics in industrial and environmental settings. However, this dual-edged sword reveals its paradox: the very agent that heals can also harm. Their ecological persistence and bioaccumulation risks disrupt microbial ecosystems, foster antibiotic resistance, and affect non-target organisms. This review navigates the fine line between pharmacological promise and environmental peril, evaluating risk assessment frameworks, mitigation strategies, and forward-looking approaches such as high-throughput screening, machine learning, and enzyme engineering. Ultimately, it advocates for a symbiotic integration of pharmaceutical innovation and environmental stewardship to create eco-friendly strategies that can enhance therapeutic efficacy without compromising ecological balance.
Keywords:
Enzyme inhibitors
therapeutic strategies
environmental impact
biofilm eradication
methanogenesis inhibitors
pharmaceuticals
environment
sustainability in drug development
Journal
C
IF:
1.8
Papers:
45
Citations:
4.3K
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Cited Papers