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Model-Informed Dosing Optimization of Colistin Sulfate in Critically Ill Patients With and Without Continuous Renal Replacement Therapy
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DOI：10.1016/j.jgar.2026.06.003.png)
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Abstract
En 中文
• This study highlights the significant influence of continuous renal replacement therapy on colistin sulfate clearance in critically ill patients, necessitating dose increase. • The duration of colistin sulfate therapy is an independent protective factor associated with clinical success. Conversely, the use of vasoactive drugs was identified as an independent risk factor for clinical success. • The study confirms that creatinine clearance is a key covariate influencing both the clearance and volume of distribution of colistin sulfate, whereas patients with mild to moderate renal insufficiency do not require dose adjustment when the MIC is ≤ 1 mg/L.
Keywords:
Colistin sulfate
Continuous renal replacement therapy
Renal function
Population pharmacokinetics
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