Modeling of Lowe patient-derived induced pluripotent stem cells into trabecular meshwork

Yang Sun

doi:10.1016/j.ajo.2026.06.013

Modeling of Lowe patient-derived induced pluripotent stem cells into trabecular meshwork

2026-06-12

0

PRE

AI

Y

Yang Sun *

T

Tia J. Kowal

Y

Yingchun Shen

J

Jingyu Zhao

B

Biao Wang

C

Chien-Hui Lo

H

Herbert M. Lachman

DOI：10.1016/j.ajo.2026.06.013

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Abstract

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• Characterization of Lowe syndrome iHTM cell lines • OCRL deficiency caused defects in phagocytosis, primary ciliogenesis, and lysosome positioning • iHTM cells as in vitro models for future mechanistic and therapeutic studies for glaucoma

Modeling of Lowe patient-derived induced pluripotent stem cells into trabecular meshwork

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