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Moderate iron restriction improves metabolism via epigenetic regulation of GDF15
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PRE
AI
J
L
A
A
J
K
A
F
刘
L
E
J
DOI：10.1016/j.jnutbio.2026.110448.png)
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Abstract
En 中文
• Severe iron deficiency causes metabolic disorder. • Moderate iron restriction improves metabolism and attenuates diet-induced obesity and metabolic derangements. • Moderate iron restriction increases H3K4 methylation and GDF15 possibly via histone demethylase JARID. • Pharmacological inhibition of H3K4 methylation or silencing GDF15 reverses metabolic improvements.
Keywords:
Moderate iron restriction
Adipose browning
GDF15
Epigenetic regulation
Metabolic health
ChIP
,
chromatin immunoprecipitation
DMT1
,
divalent metal Transporter 1
DFO
,
deferoxamine
ELISA
,
enzyme-linked immunosorbent assay
EE
,
energy expenditure
GDF15
,
growth differentiation factor 15
GFRAL
,
GDNF family receptor α-like receptor
GO
,
gene ontology
GTT
,
glucose tolerance test
gWAT
,
gonadal white adipose tissue
H3K4me
,
H3K4 methylation
HbA1c
,
hemoglobin A1c
HDAC
,
histone deacetylase
HFD
,
high fat diet
ITT
,
insulin tolerance test
iWAT
,
inguinal white adipose tissues
JARID
,
jumonji domain ARID‐containing protein
JMJD1A
,
Jumonji Domain Containing 1A
KDM5
,
Lysine demethylase 5
NF-kB
,
nuclear factor-kappa B
OXPHOS
,
oxidative phosphorylation
Pgc1α
,
peroxisome proliferator-activated receptor gamma coactivator 1-α
Tfam
,
mitochondrial transcription factor A
TET
,
ten-eleven translocation
Journal
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Papers:
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Citations:
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