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Modular brain networks shape amyloid-driven tau spread and cognitive decline
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DOI：10.1002/alz.71617.png)
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Abstract
En 中文
Alzheimer's disease involves trans-synaptic spread of tau pathology from temporal lobe epicenters, driven by amyloid beta (Aβ) deposition. How modular brain network architecture shapes this process and the ensuing cognitive decline remains incompletely understood. We tested whether the efficiency with which tau epicenters access cross-network communication pathways modulates Aβ-driven tau propagation.
Keywords:
graph theory
integration
neurodegeneration
neuroimaging
segregation
tauopathy
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