.png){kind=icon}
.png){kind=icon}
Return
Modulation of mitochondrial DNA copy number: therapeutic potential of phytochemicals and plant extracts—a comprehensive review
.png){kind=icon}
OA
AI
M
A
M
I
A
B
F
G
E
C
G
L
D
DOI：10.1007/s12272-026-01620-1.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative diseases. Recent studies have revealed that various plant-derived extracts, as well as the secondary metabolites they produce, known as phytochemicals, can modulate mtDNA-CN through mechanisms including the regulation of mitochondrial biogenesis, oxidative stress, and mtDNA repair. This review examines plant-derived extracts and phytochemical compounds from a wide range of plant species- including Ginkgo biloba, Crocus sativus, Curcumin and many others- able to modulate mtDNA dynamics, scavenging oxygen free radicals and improving antioxidant defense systems.
Keywords:
Plant extracts
Phytochemicals
Mitochondria
Mitochondrial DNA copy number
Mitochondrial function
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
7.5
Papers:
4.7K
Citations:
8.7K
Organization
Cited Papers