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Modulation of Remimazolam Placental Transfer via OATP2B1 by Rosuvastatin in an In Vitro 3D Placental Barrier Model
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DOI：10.1016/j.ejps.2026.107565.png)
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Abstract
En 中文
• The transfer of anesthetics to the fetus via the placenta during the perinatal period is a matter of concern. • It is possible to change the placental transfer rate of anesthetics by modifying the transporter function expressed on the placenta. • Remimazolam is transported via OATP2B1 and has been shown to transport via non-affinity binding sites. • Modification of OATP2B1 transport function by rosuvastatin may potentially contribute to increased fetal exposure to remimazolam at the blood-placental barrier.
Keywords:
remimazolam
placental permeability
blood-placental barrier
transporter
organic anion-transporting polypeptide 2B1(OATP2B1)
rosuvastatin
in vitro 3D model
E3S
estrone-3-sulfate
FITC-dextran 4
fluorescein isothiocyanate dextran-4
HEK293
human embryonic kidney 293 cells
HUVEC
human umbilical vein endothelial cells
OATP2B1
organic anion-transporting polypeptide 2B1
RMZ
remimazolam
RSV
rosuvastatin
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