Modulation of TLR-driven monocyte activation by JAK-STAT inhibitors in people with HIV

2026-05-04

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Camard, Mariona, b

Plaçais, Léoa, b

Bitu, Mariea

Mouanga, Christelliaha

Katia Bourdic

Rick-Ryan, Magagia

Audrey Paoletti

Bourgeois, Christinea

Lambotte, Oliviera, b

Noel, Nicolasa, b

DOI：10.1097/QAD.0000000000004530

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Chronic immune activation and systemic inflammation persist in people living with HIV (PWH) despite effective antiretroviral therapy, contributing to increased cardiovascular and cancer risk. Monocytes play a central role in this process, partly through type I interferon (IFN-I) signaling. As Toll-like receptor (TLR) 3 and 7 are key inducers of endogenous IFN-I in response to viral RNA, we investigated how TLR3 and TLR7 stimulation contributes to IFN-I–driven monocyte activation, and whether this response-potentially involving both direct TLR signaling and IFN-I mediated amplification- can be modulated by JAK-STAT inhibition.

Keywords:

Inflammation

Interferon

JAK-STAT

Monocytes

PD-L1

Modulation of TLR-driven monocyte activation by JAK-STAT inhibitors in people with HIV

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