Molecular anatomy of adult mouse leptomeninges

doi:10.1016/j.neuron.2023.09.002

Molecular anatomy of adult mouse leptomeninges

2023-12-01

35

OA

AI

Elisa Vázquez-Liébanas

M

Michael Vanlandewijck

Katrine Dahl Bjørnholm

C

Caroline Lindblad

A

Alexander Fletcher‐Sandersjöö

A. Jantine van Voorden

Maarja Andaloussi Mäe

DOI：10.1016/j.neuron.2023.09.002

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Abstract

En 中文

Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has long been debated. In this study, we iden-tify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically distinct cell types of the pia, inner arachnoid, outer arachnoid barrier, and dural border layer; and contrast them to a sixth fibroblast-like transcriptome present in the choroid plexus and median eminence. Newly identified transcriptional markers enabled molecular characterization of cell types responsible for adherence of arach-noid layers to one another and for the arachnoid barrier. These markers also proved useful in identifying the molecular features of leptomeningeal development, injury, and repair that were preserved or changed after traumatic brain injury. Together, the findings highlight the value of identifying fibroblast transcriptional subsets and their cellular locations toward advancing the understanding of leptomeningeal physiology and pathology.

Keywords:

CONTROLLED CORTICAL IMPACT

CEREBROSPINAL FLUID BARRIER

TRAUMATIC BRAIN-INJURY

ARACHNOID BARRIER

FIBROBLASTS FORM

SUBDURAL SPACE

CHOROID-PLEXUS

FIBROTIC SCAR

DURA-MATER

CELLS

Molecular anatomy of adult mouse leptomeninges

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