.png){kind=icon}
.png){kind=icon}
Return
Molecular and evolutionary processes generating variation in gene expression
.png){kind=icon}
OA
AI
DOI：10.1038/s41576-020-00304-w.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Heritable variation in gene expression is common within and between species. This variation arises from mutations that alter the form or function of molecular gene regulatory networks that are then filtered by natural selection. High-throughput methods for introducing mutations and characterizing their cis- and trans-regulatory effects on gene expression (particularly, transcription) are revealing how different molecular mechanisms generate regulatory variation, and studies comparing these mutational effects with variation seen in the wild are teasing apart the role of neutral and non-neutral evolutionary processes. This integration of molecular and evolutionary biology allows us to understand how the variation in gene expression we see today came to be and to predict how it is most likely to evolve in the future.
Keywords:
ALLELE-SPECIFIC EXPRESSION
REGULATORY DIVERGENCE
SACCHAROMYCES-CEREVISIAE
TRANSCRIPTIONAL REGULATION
MUTATION ACCUMULATION
NATURAL-SELECTION
COMPLEX TRAITS
CAENORHABDITIS-ELEGANS
ENHANCER EVOLUTION
TRANS REGULATION
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
52
Papers:
4.0K
Citations:
4.3W