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Molecular epidemiology and evolutionary analysis of multidrug-resistant Acinetobacter baumannii SToxf2499 clone at a tertiary hospital in Tianjin, China
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DOI：10.1016/j.jgar.2026.05.010.png)
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Abstract
En 中文
• This study documents the first large-scale emergence of A. baumannii SToxf2499 in Tianjin, China. • We found an extremely high prevalence of SToxf2499 A. baumannii strains which co-carriaged of blaOXA-23 and blaOXA-66 and exhibited high carbapenem resistance rate. • SToxf2499 rapidly develops multidrug resistance through the formation of IS15D1 composite transposon, thus facilitating its spread within hospital environments. • The IS15D1 composite transposon exhibited a high degree of sequence similarity and coverage with that reported in SToxf191 from South Korea.
Keywords:
Acinetobacter baumannii
carbapenem resistance
whole genome sequencing
multidrug resistance
evolution
IS15D1
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