Molecular Targets of Oleoylethanolamide in the Pathogenesis of Alcohol Use Disorder: Mechanisms of Central and Peripheral Action

Darya Ivashkevich

doi:10.1016/j.alcohol.2026.04.004

Molecular Targets of Oleoylethanolamide in the Pathogenesis of Alcohol Use Disorder: Mechanisms of Central and Peripheral Action

2026-04-18

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Darya Ivashkevich

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Igor Manzhulo *

DOI：10.1016/j.alcohol.2026.04.004

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• OEA is a multi-organ modulator targeting both the brain and periphery in AUD. • OEA reduces alcohol reward by rebalancing orexin and oxytocin systems. • OEA alleviates withdrawal-induced negative affect and neuroinflammation. • OEA protects the gut-liver axis from alcohol-induced damage and inflammation.

Keywords:

OEA

alcohol use disorder

orexin

oxytocin

gut-liver axis

Molecular Targets of Oleoylethanolamide in the Pathogenesis of Alcohol Use Disorder: Mechanisms of Central and Peripheral Action

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