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Molecular Tumor Board–Guided Osimertinib Therapy in EGFR L858R/Q701L–Mutant Lung Adenocarcinoma Supported by Functional Validation

delete2026-07-02
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OA
AI
C
Corinna Albers-Leischner *
M
Matthias Ritgen
F
Finn-Ole Paulsen
B
Benjamin Schmidt
N
Nikolas von Bubnoff
S
Sivahari Prasad Gorantla
A
Anne Letsch
M
Melanie Janning
S
Sonja Loges
C
Carsten Bokemeyer
M
Maximilian Christopeit
DOI:10.1093/oncolo/oyag242delete
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Abstract

Abstract

En 中文
Rare or compound EGFR variants in non–small cell lung cancer (NSCLC) can create substantial therapeutic uncertainty, particularly when accompanied by additional co-alterations with potential resistance implications. In such settings, molecular tumor boards (MTBs) may integrate genomic, functional, and clinical data to guide treatment selection.

Journal

T
the oncologist
IF:
0
Papers:
188
Citations:
0

Organization

U
University Hospital Schleswig-Holstein
Scholars:
501
Papers: 179
Citations: 7.7K
U
university medical center eppendorf
Scholars:
20
Papers: 12
Citations: 0
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