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Molecular versatility during pluripotency progression
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DOI：10.1038/s41467-022-35775-4.png)
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Abstract
En 中文
A challenge during development is to ensure lineage segregation while preserving plasticity. Using pluripotency progression as a paradigm, we review how developmental transitions are coordinated by redeployments, rather than global resettings, of cellular components. We highlight how changes in response to extrinsic cues (FGF, WNT, Activin/Nodal, Netrin-1), context- and stoichiometry-dependent action of transcription factors (Oct4, Nanog) and reconfigurations of epigenetic regulators (enhancers, promoters, TrxG, PRC) may confer robustness to naive to primed pluripotency transition. We propose the notion of Molecular Versatility to regroup mechanisms by which molecules are repurposed to exert different, sometimes opposite, functions in close stem cell configurations. During development the embryo must balance lineage specification against the preservation of plasticity using a limited molecular toolkit. In this Perspective, the authors propose Molecular Versatility as a paradigm for grouping molecular mechanisms that are repurposed through development to exert distinct functions.
Keywords:
EMBRYONIC STEM-CELLS
PRIMITIVE ENDODERM DEVELOPMENT
SELF-RENEWAL
FATE-SPECIFICATION
NAIVE PLURIPOTENCY
GENE-EXPRESSION
OPEN CHROMATIN
GROUP PROTEIN
GROUND-STATE
GENOME-WIDE
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15.7
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9.3W
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91.2W