Monitoring continuous mixing process dynamics through the NIR spectra baseline using a stream sampler

doi:10.1016/j.ijpharm.2025.126502

Monitoring continuous mixing process dynamics through the NIR spectra baseline using a stream sampler

2025-12-16

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Rodolfo J. Romañach *

DOI：10.1016/j.ijpharm.2025.126502

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• Stream sampler facilitates confined powder transport. • Flat surface and stable NIR spectral baseline achieved through confined powder flow. • Spectral baseline MBSD was used to monitor the mass steady state of continuous mixing. • Mass steady state occurred prior to the mixing steady states. • Mixing steady state was monitored using a PLS calibration model developed with only mean-centering.

Monitoring continuous mixing process dynamics through the NIR spectra baseline using a stream sampler

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