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Monitoring Elevated Copper Levels in Diabetic Wounds and Urine via a Hemicyanine-Based Nanoprobe
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DOI：10.1016/j.snr.2026.100483.png)
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Abstract
En 中文
• First NIR fluorescent nanoprobe (D-CRP) for real-time Cu²⁺ monitoring in diabetic wounds, addressing a critical gap in understanding copper dysregulation in diabetes. • DSPE-PEG2000 encapsulation enhances biocompatibility and stability while preserving Cu²⁺-responsive NIR fluorescence (740 nm emission). • In vivo imaging reveals elevated Cu²⁺ levels in diabetic wounds and urine, correlating with impaired healing—a previously unexplored biomarker.
Keywords:
Near-infrared fluorescent probe
Copper ion detection
Diabetic wound healing
DSPE-PEG nanoparticle
Bioimaging
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