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Mouse models of aortic aneurysm and dissection: pathophysiological insights and translational perspectives
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DOI：10.1016/j.jare.2026.07.057.png)
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Abstract
En 中文
• Summarizes major chemical, genetic, and combined models for AA and AD. • Defines how each model reveals ECM failure, SMC dysfunction, or inflammation. • Compares model strengths and limitations in mimicking human aortic pathology. • Highlights translational value of large-animal models for preclinical validation. • Introduces emerging organoid and engineered systems for mechanistic studies. • Guides rational model selection for therapeutic target discovery and testing.
Keywords:
Aortic aneurysm
Aortic dissection
Mouse models
Therapy
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13
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2.8K
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