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MRI-Derived Markers of Acute and Chronic Inflammatory Processes in the VTA Associated with Depression
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DOI：10.1016/j.bpsc.2025.09.003.png)
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Abstract
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Depression is a leading cause of disability worldwide, with inflammation increasingly recognized as a contributing factor. Inflammatory processes can disrupt the brain’s reward circuitry, particularly the ventral tegmental area (VTA), which is central to dopamine-mediated motivation and reward. This study investigates whether MRI-derived markers sensitive to neuroinflammation and microstructure in the VTA are associated with depression diagnosis and symptom severity.
Keywords:
depression
UK biobank
ventral tegmental area (VTA)
inflammation
diffusion MRI
quantitative susceptibility mapping (QSM)
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