Multi-domain based heterogeneous network for drug-target interaction prediction

Changjian Zhou

doi:10.1016/j.artmed.2026.103425

Multi-domain based heterogeneous network for drug-target interaction prediction

2026-04-09

0

PRE

AI

C

Changjian Zhou

Y

Yutong Liu

L

Lu Yu

Z

Zhenyuan Zhao

J

Jia Song *

W

Wensheng Xiang *

DOI：10.1016/j.artmed.2026.103425

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Abstract

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• A novel MHNF-DTI framework is proposed for DTI prediction. • The MHNF-DTI encodes drug structure and protein sequence simultaneously. • A multi-domain label reversal dataset is built to mitigate hidden ligand bias. • The performance of MHNF-DTI outperforms the existing state-of-the-art baselines.

Keywords:

Drug-target interaction

Heterogeneous network

Multi-domain learning

Deep learning

Computational biology

Multi-domain based heterogeneous network for drug-target interaction prediction

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