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Multi-modal magnetic resonance imaging to assess cerebrovascular function in patients with atrial fibrillation
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DOI：10.1177/0271678x261465842.png)
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Abstract
En 中文
<jats:p>
Atrial fibrillation (AF) is associated with a high risk of stroke, as well as cognitive decline and dementia. Advanced imaging techniques were employed to test the hypothesis that AF worsens cerebrovascular function as evaluated using neurovascular coupling (NVC) and cerebrovascular carbon dioxide reactivity (CVR
<jats:sub>CO2</jats:sub>
) tests. Twenty healthy controls (HC; 63.4 ± 9.5 years) and 19 AF patients (66.6 ± 12.0 years) completed NVC (visual stimulation with a flickering checkerboard) and CVR
<jats:sub>CO2</jats:sub>
(5%CO
<jats:sub>2</jats:sub>
) assessments during functional (blood oxygen level-dependent [BOLD]) and perfusion (arterial spin labelling) magnetic resonance imaging. Additionally, brain volumes and cognition were assessed. During CVR
<jats:sub>CO2</jats:sub>
assessment, neither %∆ in BOLD signal (HC: 3.09 ± 0.50; AF: 3.23 ± 0.70%;
<jats:italic toggle="yes">p</jats:italic>
= 0.513) nor %∆ in cerebral blood flow (CBF) (HC: 36.6 ± 18.8; AF: 43.6 ± 20.6%;
<jats:italic toggle="yes">p</jats:italic>
= 0.319) were different between groups. During NVC assessment, CMRO
<jats:sub>2</jats:sub>
(HC: 5.25 ± 1.84; AF: 4.36 ± 2.50%,
<jats:italic toggle="yes">p</jats:italic>
= 0.285), %∆BOLD (HC: 1.60 ± 0.38; AF: 1.66 ± 0.79%;
<jats:italic toggle="yes">p</jats:italic>
= 0.762) and %∆CBF (HC: 49.4 [20.1–71.9]; AF: 51.7 [38.3–66.9]%;
<jats:italic toggle="yes">p</jats:italic>
= 0.850) all increased similarly in HC and AF. AF patients had lower hippocampal volume relative to total intracranial volume than HC (0.50 ± 0.06 vs 0.55 ± 0.06%;
<jats:italic toggle="yes">p</jats:italic>
= 0.020). There were no differences between HC and AF in cognitive performance across multiple domains (all
<jats:italic toggle="yes">p</jats:italic>
> 0.05). These results suggest that NVC and CVR
<jats:sub>CO2</jats:sub>
responses are preserved in AF.
</jats:p>
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