Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention

Yuxuan Weng

doi:10.1016/j.metabol.2026.156734

Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention

2026-08-11

0

PRE

AI

Y

Yuxuan Weng

M

Mingyi Du

T

Tianhao Wu

L

Linyao Lu

蒋

蒋艳峰 (Yanfeng Jiang)

索

索晨 (Chen Suo)

李金 (Jin Li)

T

Tiejun Zhang *

陈

陈兴栋 (Xingdong Chen) *

刘

刘振球 (Zhenqiu Liu) *

DOI：10.1016/j.metabol.2026.156734

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Abstract

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• MASLD comprises three genetic subtypes with distinct biological roots. • All subtypes increase liver disease risk but diverge in cardiometabolic outcomes. • Plasma protein signatures distinguish each subtype and link them to systemic disease. • Both established and potentially novel protein targets emerged as candidates for personalized prevention.

Multi-omics dissection of MASLD reveals divergent pathways to systemic diseases and targets for prevention

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