Multi-omics mechanistic investigation of Yograj Guggulu, an Ayurvedic polyherbal formulation, against MIA-induced osteoarthritis in rats

Amay Sanjay Redkar

doi:10.1016/j.jep.2026.122058

Multi-omics mechanistic investigation of Yograj Guggulu, an Ayurvedic polyherbal formulation, against MIA-induced osteoarthritis in rats

2026-06-16

0

PRE

AI

A

Amay Sanjay Redkar

A

Arun Surendran

B

Bishal Rajdev

N

Neethu Prasad

A

Arun N. Prakash

D

Dikshita Hazarika

I

Ilackkeya Bhavananthi

N

Naveen Kumar

G

Gajji Babu

Y

Y.R. Sanjaya Kumar

N

Narayanam Srikanth

R

Rabinarayan Acharya

A

Abdul Jaleel

V

V.G.M. Naidu

C

Chandrasekharan C. Kartha

S

Sharad Pawar *

V

Vibin Ramakrishnan *

DOI：10.1016/j.jep.2026.122058

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Abstract

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• Ayurvedic formulation Yograj Guggulu restores joint function in a rat OA model. • 23 bioavailable metabolites converge on four human OA network targets. • 364 disease-associated knee-joint proteins attenuate after treatment. • Shortest-path analysis connects metabolite targets to proteomic attenuation.

Multi-omics mechanistic investigation of Yograj Guggulu, an Ayurvedic polyherbal formulation, against MIA-induced osteoarthritis in rats

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