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Multi-omics reveals an extracellular vesicles-mediated susceptibility: Conferring carbenicillin resistance while compromising copper tolerance in Vibrio parahaemolyticus
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DOI：10.1016/j.ecoenv.2026.120598.png)
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Abstract
En 中文
• EVs mediate antibiotic resistance via target concealment, downregulating porin OmpU and PBP2. • EV-induced metabolic reprogramming toward amino acid scavenging supports survival under carbenicillin stress. • EVs suppress copper efflux (CusRS) and iron acquisition (TonB) under combined antibiotic and copper stress. • EV-driven PTS hyperactivation causes metabolic burnout, increasing bacterial vulnerability to heavy metals. • A molecular framework shows EV-mediated resistance as a double-edged sword in multi-stress environments.
Keywords:
Vibrio parahaemolyticus，Extracellular vesicles (EVs)
Carbenicillin and copper
Transcriptomic analysis
Susceptibility
Journal
E
IF:
6.1
Papers:
1.8W
Citations:
6.9W
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Cited Papers