Multi-Path Neural Mechanisms of Self–Other Reward Integration Impairment in Schizophrenia

2026-04-27

PRE

ChaoZheng Huang

Hanbin Sang

Xuan Zhao

Pei Xie *

Aibao Zhou *

DOI：10.1016/j.neubiorev.2026.106715

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• Synthesizes behavioral and neuroeconomic findings (effort-based choice, social reinforcement learning, dictator/trust/public-goods games) showing mis-weighting, mis-learning and mis-attribution of outcomes when actions jointly affect self and others. • Proposes a four-path multi-level model in which imprecise social priors, aberrant salience/prediction errors, biased effort–cost computation and disturbed self–other boundaries jointly generate self–other reward integration impairments. • Maps these paths onto specific neural and neuromodulatory systems, highlighting convergent dysfunction in mentalizing, salience/reward and control networks under dopaminergic and oxytocinergic modulation.

Keywords:

effort-based choice

social reinforcement learning

self–other reward integration

schizophrenia

neural mechanisms

Multi-Path Neural Mechanisms of Self–Other Reward Integration Impairment in Schizophrenia

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