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Multicolor, injectable BSA-based lanthanide luminescent hydrogels with biodegradability
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DOI：10.1016/j.ijbiomac.2023.123865.png)
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Abstract
En 中文
Protein hydrogels have attracted increasing attention because of their excellent biodegradability and biocom-patibility, but frequently suffer from the single structures and functions. As a combination of luminescent ma-terials and biomaterials, multifunctional protein luminescent hydrogels can exhibit wider applications in various fields. Herein, we report a novel, multicolor tunable, injectable, and biodegradable protein-based lanthanide luminescent hydrogel. In this work, urea was utilized to denature BSA to expose disulfide bonds, and tris(2-carboxyethyl)phosphine (TCEP) was employed to break the disulfide bonds in BSA to generate free thiols. A part of free thiols in BSA rearranged into disulfide bonds to form a crosslinked network. In addition, lanthanide complexes (Ln(4-VDPA)3), containing multiple active reaction sites, could react with the remaining thiols in BSA to form the second crosslinked network. The whole process avoids the use of nonenvironmentally friendly photoinitiators and free radical initiators. The rheological properties and structure of hydrogels were investi-gated, and the luminescent performances of hydrogels were studied in detail. Finally, the injectability and biodegradability of hydrogels were verified. This work will provide a feasible strategy for the design and fabrication of multifunctional protein luminescent hydrogels, which may have further applications in biomedi-cine, optoelectronics, and information technology.
Keywords:
Protein hydrogels
Multicolor luminescence
Injectability
Journal
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8.5
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4.9W
Citations:
21.7W