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Multifractal Analysis of Ion-Channel Currents: A Comparative Study of the WTMM and MFDFA Approaches
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DOI：10.3390/membranes16080261.png)
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Abstract
En 中文
The multifractal properties of ion-channel currents recorded from Beta vulgaris L. vacuoles were analyzed using multifractal detrended fluctuation analysis (MFDFA) and the Wavelet Transform Modulus Maxima (WTMM) method. The study covered a range of membrane potentials, different incubation times with indole-3-acetic acid (IAA), and regimes with single and multiple active channels. Clear multifractal behavior was observed, with the spectrum width, Δ α , varying with voltage, biochemical modulation, and channel occupancy. A comparative analysis shows that WTMM provides a more reliable and detailed characterization of the scaling properties. In particular, WTMM yields stronger nonlinearity in the scaling exponents τ ( q ) , clearer scaling regimes, and higher sensitivity to variations in Δ α , whereas MFDFA results are affected by deviations from ideal scaling. The presence of multiple channels introduces a structured, non-monotonic dependence of Δ α on voltage, indicating collective dynamics. These results demonstrate that WTMM is better suited for analyzing nonstationary, dichotomous ion-channel signals.
Keywords:
SV channel
patch clamp
multifractal analysis
WTMM
time series analysis
long memory effect
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