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Multifunctional elliptical magnetic nanocarriers for dual-responsive targeted antitumor therapy
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DOI：10.1007/s10934-025-01895-7.png)
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Abstract
En 中文
This study developed a multifunctional drug delivery system, HMNPs-C60-N-GQDs-SS-PEI, based on elliptical hollow magnetic mesoporous silica nanoparticles (HMNPs). It integrates magnetic targeting, fluorescence imaging, and pH/redox dual-responsive release for efficient delivery and controlled release of gambogic acid (GA). The elliptical nanocarrier's surface was modified with C60, nitrogen-doped graphene quantum dots (N-GQDs), disulfide bonds (-SS-), and polyethyleneimine (PEI). The system shows high GA loading (89.72%), sustained release (47.58% cumulative release over 220 h), and responsive release under acidic (pH 5.7) and high-glutathione (GSH) tumor conditions. The developed elliptical nanocarriers showed excellent drug loading and release performance. The encapsulation efficiency increased from 60.57% to 89.72%, while the cumulative sustained release rate improved from 30.45% to 47.58% under pH 5.7 and reductive (GSH) conditions. The carriers achieved a maximum sustained release of 30.69% within 220 h with an optimal encapsulation efficiency of 76.35%, demonstrating the strong influence of C-6(0) modification and the synergistic effect of N-GQDs and PEI functionalization. In vitro and in vivo experiments confirmed strong inhibition of SMMC-7721 liver cancer cell growth via magnetic targeting, reducing tumor volume to 0.023. It also shows low cytotoxicity, good renal clearance, and liver accumulation of 121.19% ID/g at 120 min post-administration, offering a promising approach for precise anti-tumor therapy.
Keywords:
Elliptical drug delivery
Disulfide bonds (-SS-)
Magnetic targeted treatment
pH/REDOX-responsive
Gambogic acid
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3.2
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154
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5.0K
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