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Multifunctional laminarin-chitosan composites loaded with bromelain nanoflowers: a biohybrid design approach
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DOI：10.1016/j.matdes.2025.115374.png)
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Abstract
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• Soft chitosan–laminarin sponges were modified with bromelain and Mannich base. • Enzymatic and contact-active antibacterial effects acted synergistically. • Antibacterial activity increased more than twofold compared to the control. • The material enhanced fibroblast migration and showed wound healing potential. • A multifunctional biohybrid was developed for advanced biomedical applications.
Keywords:
Bromelain nanoflowers
Laminarin
Laminarin dialdehyde
Mannich base, antimicrobial properties
Biohybrid wound care materials
Contact-active biomaterial
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