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Multifunctional ROS-responsive hydrogels alleviate subconjunctival inflammation
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DOI：10.1039/D5TB01859E.png)
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Abstract
En 中文
Persistent subconjunctival inflammation poses a significant risk for progression to vision-threatening complications such as fibrosis. Existing pharmacological interventions are limited by their administration constraints and potential bio-toxicity issues; failing to adequately address clinical requirements. There is an urgent need for effective methods to inhibit subconjunctival inflammation. Here; we prepared a multi-network hydrogel (CPES) with reactive oxygen species (ROS) scavenging properties via a one-step mixing process to suppress early subconjunctival inflammation. Due to its unique crosslinked structure; primarily comprising dynamic borate esters and thioether; CPES exhibits controllable biodegradability and ROS scavenging capacity. Experimental results reveal that CPES hydrogels possess ideal gelation stability; adequate swelling rates; robust self-adaptive and self-repair capabilities; free radical scavenging capacity; good cell compatibility; and inflammation restrain capabilities. In a rat model of subconjunctival injury inflammation; CPES effectively controlled early inflammation. Collectively; these findings establish CPES as a promising therapeutic platform for controlling subconjunctival inflammation.
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