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Multimodal AI generates virtual population for tumor microenvironment modeling
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DOI：10.1016/j.cell.2025.11.016.png)
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Abstract
En 中文
• GigaTIME uses multimodal AI to translate H&E pathology slides to spatial proteomics • GigaTIME generates a virtual population with cell states from routine H&E slides • Virtual population enables large-scale clinical discovery and patient stratification • Virtual population reveals new spatial and combinatorial protein activation patterns
Keywords:
multimodal AI
precision health
tumor microenvironment
digital pathology
real-world evidence
spatial proteomics
virtual population
real-world data
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