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Multimodal physiological responses evoked by emotional naturalistic stimuli facilitate classification of major depression and generalized anxiety
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DOI：10.1016/j.jad.2026.122323.png)
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Abstract
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• A novel framework integrating naturalistic stimuli with multimodal physiological recordings for classifying MDD and GAD. • The emotional naturalistic stimuli paradigm effectively elicits disorder specific physiological patterns in MDD and GAD. • Early fusion of eye-tracking, heart rate variability, and electrodermal activity achieves best classification performance. • EDA responses to fear stimulus are the most significant contributors to differentiating MDD from GAD.
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